SCIENTIFIC EVIDENCE

A cell-type-specific epigenetic mechanism encodes social investigatory behavior via Lrhcn1 and Hcn1.

Science advances
Qin P, Zhao W, Zhou X, Guo Y, Li L, Liu Z, Shen X, Yang C, Tang X, Yu D, Zhu M, Wu S, Cheng L, Yang J, Li X, Li H, Zhu LQ, Jing W, Du HY, Liu D, Lu Y.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2025
Single-Cell Analysis
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Key Finding
The authors integrated a genetically guided TRAP2 strategy with single-cell Ca 2+ image and found that activity dynamics of serotonin receptor 2c (Htr2c)-expressing neurons in the prelimbic cortical layer 5 encode high social states. Gain- and loss-of function studies demonstrated that this projection specifically processes socially conveyed information.
Countstar Connection
Countstar (model not specified) quantified cell measurements in cell suspensions before single-cell analysis in the 2025 Science advances study.
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