SCIENTIFIC EVIDENCE

1-Pyrroline-5-carboxylate inhibit T cell glycolysis in prostate cancer microenvironment by SHP1/PKM2/LDHB axis.

Cell communication and signaling: CCS
Chang L, Li G, Jiang S, Li J, Yang J, Shah K, Zhou L, Song H, Deng L, Luo Z, Guo Y, Yan Y.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2024
Cancer Research
Immunology
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Key Finding
P5C also inhibits the activity of PKM2 and decreases the content of intracellular lactic acid while increasing the activity of LDH. The study revealed that P5C inhibits the process of glycolysis in T cells by targeting SHP1/PKM2/LDHB complexes.
Countstar Connection
The study's cell samples underwent cell-count assessment with Countstar (model not specified) during quality assessment for the cancer-model experiments.
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