The team transplanted stem cells into the human body for the first time
Stem cells have been successfully transplanted into the human body for the first time.
According to popular science on November 11, luz douai and his team from Pierre and Marie Curie university in Paris, France, have successfully transplanted blood from stem cells into the human body for the first time.
Douai's team first drew hematopoietic stem cells from a volunteer's bone marrow and then used a cocktail of growth factors to stimulate the cells to bind to red blood cells. After tagging the artificial cells for tracking, they injected 10 billion of them (equivalent to 2 milliliters of blood) back into the donor.
Five days later, at least 94 percent of the artificial blood cells were still circulating in the donor's system. After 26 days, 41 to 63 percent of the blood cells were still alive. These artificial blood cells are just as efficient as natural cells at delivering oxygen throughout the body.
This is good news for the international medical community, Duneie said. “The results suggest that the end of the blood shortage may be near.” Despite the increasing number of blood donors in developed countries, the world still faces a serious blood shortage. In areas with high incidence of AIDS, blood shortage is even more serious.
At present, there are many research teams in the world studying "artificial blood". But other attempts at synthetic blood have focused on creating substitutes for natural blood, rather than growing it artificially. For example, Chris cooper's team at the university of Essex, UK, is working on a hemoglobin-based blood substitute. The artificial blood provides a solution for transfusions caused by natural diseases, especially in remote areas, because it does not need to be refrigerated like fresh or stem-cell blood, and it is easy to preserve.
Stem-cell hematopoiesis, which is more similar to current blood transfusions, has its own advantages, which should allay concerns about the safety of the current phase of artificial blood.
Although the research, published in the medical journal blood, is a major advance in the field of stem-cell hematopoiesis, it is still a long way from producing artificial blood on a large scale, as the amount of blood transfused in this experiment is only about 1/200 of the volume of a typical patient's blood transfusions.
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