The research team transplant stem cells into the human body for the first time
Stem cell hematopoietic that is transplanted into the human body got the first success.
According to popular science on November 11, Luz Douai and his team from Pierre and Marie Curie university in Paris, France, have successfully transplanted blood from stem cells into the human body for the first time.
Douai's team first drew hematopoietic stem cells from a volunteer's bone marrow and then used a cocktail of growth factors to stimulate the cells to bind to red blood cells. After tagging the artificial cells for tracking, they injected 10 billion of them (equivalent to 2 milliliters of blood) back into the donor.
Five days later, at least 94% of the artificial blood cells were still circulating in the donor's system. After 26 days, about 41% to 63% of the blood cells were still alive, as were the survival rates of natural blood. These artificial blood cells are just as efficient as natural cells at delivering oxygen throughout the body.
This is a great new for the international medical community, said Douai. "the results of this experiment suggest that the day of the blood shortage may about to end." Despite the increasing number of blood donors in developed countries, the world still faces a serious blood shortage. In areas with high incidence of AIDS, blood shortage is even more serious.
At present, there are many research teams in the world studying "artificial blood". But other attempts to synthesize blood have focused on creating alternatives to natural blood, rather than growing it artificially. For example, Chris cooper's team at the university of Essex in the UK is working on a hemoglobin-based blood substitute. The artificial blood provides a solution to transfusions caused by natural diseases, especially in remote areas, because it is easier to preserve than fresh or stem-cell blood, which requires refrigeration.
Stem-cell hematopoiesis has its own advantages. It is more similar to the current blood transfusion method, which can alleviate people's concerns about the safety of the current stage of artificial blood.
Although the research, published by Douai in the medical journal blood, is a major advance in the field of stem-cell hematopoiesis, it is still a long way from being used to produce artificial blood on a large scale, as the amount of blood transfused in this experiment is only about 1/200 of the volume of a typical patient's blood transfusions.
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