The newest research progress of hematopoietic stem cells in university of Toronto
The main stem cells isolated could be used for hematopoietic functions in humans, according to the Toronto University Health Network on July 8.
For decades, the scientific community has believed that Mother Cells and blood-forming Cells exist in the body, and that bone marrow helps the body replenish fresh blood. Bone marrow transplants are used to treat blood disorders such as leukemia or genetic and rare diseases, but only if the patient matches the donor's stem cells.
By narrowing the field, researchers have identified stem cells that help the body produce blood, opening a door of hope for patients with blood cancer or other blood disorders.
Researchers at the university of Toronto say they have found that such mother cells, called hematopoietic stem cells (HSCs), help regenerate all types of blood cells, including red blood cells, lymphocytes and Macrophages.
The discovery meant a better understanding of the body's hematopoietic system, said John Dick, a senior fellow at the Ontario Cancer Institute and McEwen Center for Regenerative Medicine.
Dick and the team transplanted human bone marrow and blood extract to mice immune system, through the scan cell surface with a special protein biomarkers, the 10000 May be narrowed down to hematopoietic stem cells, and the 10000 cells have the same biomarkers, then through long-term test, using the method ultimately selected hematopoietic stem cells, called CD49f.
According to Dick and his team, CD49f biomarkers are extremely rare in humans, only happened one in every three million cells.
Now, the team's next goal is to further test whether these CD49f cells are safe enough to help patients successfully regenerate their blood systems.
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