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The chief scientist of “973” explains the mechanism of stem Cell aging in Aging Cell

Recently, researchers from the institute of animal sciences of the Chinese academy of sciences confirmed that dermal stem cells will undergo a cellular senescence phenomenon when the environment changes, and this phenomenon will eventually lead to the loss of self-renewal ability of dermal stem cells. Dermal stem cells of different ages have different resistance to the process of cell senescence. The study appears in the August issue of the journal Aging Cell.

Duan Enkui, head of the embryology research group at the institute of zoology, Chinese academy of sciences and chief scientist of the 973 project, led the research. Its important research direction is the regulation and induction of the proliferation and differentiation of embryonic implantation and adult stem cells. So far, more than 70 SCI papers have been published, 2 patents for new methods of skin stem cells have been independently applied, and 3 cover papers have been published in mainstream journals in the field of stem cells. The co-first authors are assistant researcher Dr. Shuang liu and doctoral candidate Dr. Shu liu. The research was funded by the Chinese academy of sciences' special program of strategic leading science and technology and the national major scientific research program of "development and reproduction research".

The study of adult skin stem cells is of great significance for treating burns, diabetic skin ulcers, skin aging and constructing human tissue-engineered skin. At present, the application of skin stem cells for tissue engineering of skin construction and treatment of skin diseases is still in the initial stage, but at the same time, the clinical demand for the application of adult skin stem cells is urgent. The self - renewal and differentiation of different skin stem cells in vitro are the key scientific problems that need to be solved.

In the new paper, Duan Enkui's research group confirmed through a series of experiments that the senescence of dermal stem cells is closely related to the pi3k-akt signaling pathway: the application of LY294002 and Akt inhibitor VIII to inhibit this signaling pathway can rapidly promote dermal stem cells into the state of cell aging; On the contrary, adding pdgf-aa and BPV (PIC) to activate this pathway can effectively inhibit the aging of dermal stem cells and promote their self-renewal without affecting the differentiation ability of the cells.

This study not only laid a foundation for exploring the cellular and molecular mechanism of human skin aging, but also provided theoretical basis and technical support for the future application of adult skin stem cells in the construction of tissue engineering skin and the application of regenerative medicine and translational medicine in the treatment of skin related diseases.
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