Shi Yufang: Response Mechanism of Mesenchymal Stem Cells and Tissue Immune

Recently, at the invitation of Trends in Immunology magazine of Cell Press, the immunological and tissue stem cell research group led by Yuhuang Researcher, Shanghai Academy of Life Sciences, Chinese Academy of Sciences, Shanghai Jiaotong University Medical College, published an article, an online review of the research entitled "How mesenchymal stem cells interact with tissue immune responses" in January 2012.
This review is based on the main research results of Yuhuang Research Group on mesenchymal stem cell immunology in recent years and the latest progress in this field. The interaction and mechanism between mesenchymal stem cells and immune system, the role of mesenchymal stem cells in the pathogenesis of diseases, the impact of wound healing and its broad prospects in clinicalapplication are systematically elaborated, and the concerns in this field urgently need to be answered are put forward. Key problem.
Mesenchymal stem cells (MSCs) are tissue stem cells in bone marrow excepthematopoietic stem cells. They are widely distributed in bone marrow, liver, fat, umbilical cord and other tissues, and have strong self-renewal ability and multidirectional differentiation potential. Therefore, mesenchymal stem cell transplantation has broad application prospects in the field of regenerative medicine. At the same time, as an important immunoregulatory cell, MSCs have a strong regulatory effect on the immune system after stimulation by inflammatory cytokines, so MSCs are expected to be used in the treatment of autoimmune diseases such as systemic lupus erythematosus. Under the leadership of the researcher Yuhuang at that time, the researcher of the research group carried out systematic research on the interaction between mesenchymal stem cells and the immune system, clarified the specific regulatory mechanism of mesenchymal stem cells for the immune system, greatly enriched people's understanding of mesenchymal stem cells, and achieved remarkable results in this field, which attracted wide attention from International colleagues.
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