Shenyang military region general hospital has successfully carried out multi-target transplantation

At the first few days of September, the method of neural stem cell transplantation using microelectrode guided stem cell intracerebral multi-target transplantation initiated by li zhiyong, deputy director of neurosurgery department of Shenyang military region general hospital, has been successfully applied in clinical practice.

Under normal circumstances, the neural stem cell transplantation is mostly completed through cerebrospinal fluid circulation or peripheral blood circulation through spinal canal or ventricular injection, but the transplanted stem cells are difficult to pass the blood-brain barrier, and the therapeutic effect is still not good enough. However, at present, almost all the brain stem cell transplantation carried out in China put stem cells into hematoma cavity, and there are adverse factors such as glial scar and residual degenerative metabolites to inhibit or destroy stem cells. Aiming at the current situation, Li Zhiyong after a large number of literature investigation, combined with clinical cases, director of the research, based on the proposed by MR (mri) of the DTI) (white matter fiber in imaging imaging display of nerve fiber break away from the point as the reference area, through collecting reference area of neuron discharge and micro electrodes to stimulate the method of observation of phantom limb movement, through double judgment to find out the brain injury, nerve fibers as targets for stem cell transplantation, then target accurate inject stem cells transplantation on "microelectrode guided stem cells in the brain more targets transplant" technology.

Its biggest characteristic is to put stem cells in the most needed place through the highest density, the most direct way and the most accurate technology, avoiding the difficulties of previous brain transplantation of stem cells, at the same time, nerve fiber repair or regeneration can be observed through indirect or direct methods, Currently, they have treated 2 patients with this method, and both of them were able to find the disconnection point of nerve conduction pathway quickly and accurately during the operation. In clinical practice, on the day of stem cell implantation, the patient's abnormal sensation such as "pain in the affected limb" and "facial numbness" disappeared, and the muscle strength of the affected limb increased by 1-2 levels the day after transplantation. After one to two months, the neurological function of the patients was significantly improved compared with that of the patients without stem cell transplantation.
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