Shenyang military region general hospital has successfully carried out multi-target transplantation

In early September, Li zhiyong, deputy director of the neurosurgery department of shenyang military region general hospital, initiated the microelectrode guided stem cell intracerebral multi-target transplantation technique for neural stem cell transplantation, which has been successfully applied in clinical practice.

Under normal circumstances, the neural stem cell transplantation is mostly completed through spinal canal or intraventricular injection through cerebrospinal fluid circulation or peripheral blood vessel injection through blood circulation, but the transplanted stem cells are difficult to pass the blood-brain barrier, and the treatment effect is not good. However, almost all of the brain stem cell transplantation carried out in China put stem cells into hematoma cavity, and there are adverse factors such as glial scar and residual degenerative metabolites to inhibit or destroy stem cells. Aiming at the status quo, Li Zhiyong after a large number of literature investigation, combined with clinical cases, director of the research, based on MR to propose in DTR (white matter fiber in imaging) imaging display of nerve fiber break away from the point as the reference area, through collecting reference area of neuron discharge and micro electrodes to stimulate the method of observation of phantom limb movement, through double judgment to find out the brain injury, nerve fibers as targets for stem cell transplantation, then target accurate inject stem cells transplantation on "microelectrode guided stem cells in the brain more targets transplant" technology.

It is characterized by the highest density, the most direct way and the most accurate technology to put stem cells in the most needed place, avoid the difficulties of previous stem cell brain transplantation, at the same time, through indirect or direct methods, can observe nerve fiber repair or regeneration. So far, they have treated 2 patients with this method, and the disconnection point of nerve conduction pathway can be found quickly and accurately during the operation. In clinical practice, on the day of stem cell implantation, the patient's abnormal sensation such as "pain in the affected limb" and "facial numbness" disappeared, and the muscle strength of the affected limb increased by 1-2 levels the day after transplantation. After one to two months, the neurological function of the patients was significantly improved compared with that of the patients without stem cell transplantation.
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