Scientists have Successfully Transformed Embryonic Stem Cells into Thyroid Cells
Researchers from Boston University Medical School have successfully regenerated thyroid cells from genetically modified embryonic stem cells in a study published recently in the International Journal Stem Cell Reports. For the first time, researchers have used similar steps based on human stem cells to better simulate them. It can help us better understand the causes of thyroid diseases and provide some new ideas for the treatment.
In the United States, thyroid diseases affect about 10% of the population. Thyroid diseases include Graves'disease and Hashimoto's disease, which can lead to hyperthyroidism, thyroid nodules, goiter or cancer.
Researchers engineered mouse embryonic stem cells cultured in the laboratory to express a special gene: Nkx2-1, which is important for thyroid development. When the researchers briefly turned on/off the Nkx2-1 gene, they guided embryonic stem cells through several steps. The results showed that the gene was expressed in the following three steps: In a very narrow time frame, turning on the expression of Nkx2-1 can transform most embryonic stem cells into thyroid cells.
Dr. Laertis Ikonomou pointed out that this new method can help us produce a large number of targeted cell types: thyroid cells, while it can also be used to study other clinically related cell types, such as lung cells, insulin-producing cells and liver cells. Researchers hope that this study will help develop therapeutic or stem cell-based engineering technologies to improve the quality of life and health of patients with thyroid and other diseases.
- April 8, 2018Countstar® attended the 27th annual ESACT-UK meeting on the 11-12th January 2017 in Oxford, UK. During the meeting, Countstar® not only brought a convenient solution for cell counting but also...view
- May 16, 2019Neural stem cells may help brain tumor patients repair impaired cognitive function in animal studies, us researchers report. Researchers at the university of California, irvine, created mice with brai...view
- May 16, 2019The researchers say individual cells of E. coli produce spikes of electricity similar to the firing of neurons. Like all living organisms, E. coli uses voltage to communicate information. Before that,...view