Researchers at the nutrition institute of the Shanghai academy of life sciences have discovered a ne
The epicardium is a membrane of mesenchymal cells on the surface of the heart. It plays an important role in the development of the heart. A heart without an epicardium does not develop properly, and the mice die early in the embryo. Although the epicardium plays an important role in the development of the heart, it is not clear how it functions in the repair of damaged adult hearts.
Shanghai life science college nutrition blowing by William team and harvard medical school in Boston children's hospital Pu team cooperation, the use of transgenic mouse models found epicardial cells after heart damage occurs epithelial mesenchymal transition (EMT), ectomesenchymal cells form, by a large number of promoting secreted angiogenic factors, promote heart coronary endothelial cell proliferation, thus improving the recovery of cardiac function after myocardial infarction. This work provides a new idea for the clinical treatment of myocardial infarction and the research of cardiac regeneration.
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