Serine threonine kinase 17A (STK17A) plays different roles in different tumors and may inhibit or promote cancer, depending on the type of cancer. But until now researchers have not understood its role in colorectal cancer.
Doctor Christopher Williams and Doctor Sarah Short and other colleagues found that STK17A expression was down-regulated in both primary colorectal cancer and distant metastatic lesions. Down-regulation of STK17A in colorectal cancer cell lines will lead to changes related to epithelial mesenchymal transformation, and this process will make previously closely connected cancer cells become cancer cells with migration ability and invasion ability, thus enhancing the ability of cancer metastasis.
The researchers found a similar downregulation of STK17A in patient-derived tumor-like organs. The study was published in Molecular Cancer Research ", entitled "Serine Threonine Kinase 17 a maintains the epithelial state in colorectal Cancer cells", the study reveals the STK17A in regulating the new role in the epithelial cell types, shows that STK17A absence may lead to settlement colorectal Cancer invasion and metastasis.
Since most colorectal cancer-related deaths are because of metastasis, it is of clinical significance to identify the relevant signaling pathways that lead to colorectal cancer metastasis. Therefore, this study provides a new breakthrough for the prevention and treatment of colorectal cancer metastasis.