PNAS：Embryonic stem cell therapy is an important achievement
Researchers from the university of wisconsin-madison published an article entitled "Human embryonic stem cells-derived regulatory adopt and regulate the activity of an established neural network", demonstrating that neurons derived from embryonic stem cells can regulate the behavior of the host neural network, which is a key step towards successful cell transplantation therapy for neurological diseases. The results were published in the journal proceedings of the national academy of sciences.
Previous studies have shown that human neurons derived from stem cells, when transplanted into rat brains, can integrate with the main neurons in the rat brain and receive signals from them. But scientists have not shown that the transplanted cells can successfully signal and regulate the activity of the master neurons.
In this paper, neurons from human embryonic stem cells (hESCs) that were photoactivated were transplanted into the brains of mice with various neurodegenerative diseases to analyze the ability of human cells transplanted in vitro and in mouse brains to integrate into mouse neurons.
Found that neurons from human embryonic stem cells can be in live mice brain function integration, this may be for the research and development for Parkinson's disease, alzheimer's disease, stroke, and the new treatment of epilepsy is of great significance, the article corresponding author Jason p. Weicka said, this is incredible, now, in essence, we can customize for specific disease neurons.
The researchers cultured these human cells with mouse neurons, showing synchronized neural activity. Although neurons from human embryonic stem cells do not normally exhibit this behavior, these human cells gradually show impulsive activity during the growth of neurons with mice. In addition, stimulating these human neurons with light triggered impulsive behavior in mouse neurons, suggesting that human and mouse neurons interact. Light stimulation also triggered the response of neurons from brain slices of mice transplanted from human embryonic stem cells, suggesting that transplanted neurons can be functionally integrated into the neural network and control the activity of the neural network.
"It's very exciting," says Song hongjun of Johns Hopkins university in the United States. "you can put a small number of cells in and get a huge effect." Researchers are now transplanting these light-activated neurons into the brains of mice with various neurodegenerative diseases.
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