New Advances in Stem Cell Therapy

1. SERAXIS introduced stem cell derived pancreatic cells to reverse diabetes.

On September 5, SERAXIS, a regenerative medicine company, announced the successful production of stem cell-derived pancreatic cells that regulate blood glucose in insulin-dependent diabetes mellitus in rodent models. The findings were published in the PLOS ONE magazine this week. This study describes a new method to produce insulin secreting beta cells in islet like cell clusters. SERAXIS researchers have further shown that islet cell clusters act like mature islets, secreting insulin shortly after transplantation in response to glucose fluctuations in diabetic rodent models. These unique islet-like cell clusters are derived from stem cells, which are derived from induced pluripotent stem cell (ipsC) technology and have pancreatic properties. It is reported that the purity of SERAXIS islet-like cells is very important for clinical research and application, and can produce glucagon, suggesting that SR1423 cells exist physiologically related ways to control glucose.

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2. Nature: Salk Research finds that stem cells can turn wounds into skin.

A technique developed by scientists at the Salk Institute, published in the September 5 issue of the Journal Nature, turns cells from open wounds directly into new skin cells. This approach relies on reprogramming cells into stem-like states, which can be used to cure skin damage, resist the effects of aging, and help us better study skin cancer. "Our observations provide preliminary evidence for the regeneration of entire three-dimensional tissues (such as skin) in vivo, not just the single cell type shown previously," said Professor Juan Carlos Izpisua Belmonte, senior author of the paper. "This knowledge is not only helpful in strengthening skin repair, but also can be referred  to conducting in vivo regeneration of other human pathologies, in vivo regeneration of aging processes, and strategies for tissue repair damage. Researchers are planning to do more research to optimize the technology and begin testing it in other ulcer models.

3. Nature: healthy adults have 5-20 blood stem cells, 10 times higher than previously thought.

On September 5, a new study from the Wellcome Sanger Institute and the Wellcome-MRC Stem Cell Institute was published in the Journal Nature. MRC has developed a new method of studying stem cells based on ecological methods. In this study, the researchers sequences the entire genome of 140 blood stem cell colonies from a healthy 59-year-old man. The team "tag" the stem cells and compare them to the blood cell population using a method traditionally used to ecologically monitor species populations. The results showed that adult bone marrow contained more blood stem cells than previously thought, ranging from 50,000 to 200,000 stem cells.

This is the first time scientists have been able to determine how many blood stem cells work in a healthy human body, providing a new opportunity to study changes in stem cells throughout the body during aging and disease. Using genome-wide sequencing to construct and analyze cell family trees, this work provides insight into how cancer develops and why some stem cell analysis therapies are more effective than others are.

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