Nature: To reveal how do cancer stem cells construct their own niches
On January 5, Nature magazine published the latest research results of Swiss and Chinese scientists "Interactions between cancer stem cells and their niche govern metastatic colonization". In the paper, the authors reveal how cancer stem cells construct their own niches.
Experiments with a mouse model of breast tumors, in which tumor cells naturally migrate to the lungs, have shown that to colonize metastatic tumor cells, a small number of permeable cancer stem cells are needed. These cells induce the expression of an extracellular protein, "periosteal protein," which supports the growth of transferases in the formed microenvironment by enhancing Wnt signaling in tumor cells. The blocking of the function of "periosteum protein" prevents the progression of metastasis, indicating that in the early stage of metastasis, when tumor cells are likely to have special dependence on the signal in the microenvironment, treatment targeting the metastatic microenvironment may have therapeutic potential.
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