Japanese team finds' magic gene 'in ips cells

Professor shinya yamanaka, director of the institute of Induced Pluripotent Stem Cells (ips) at Kyoto university, and his team have discovered the Glis1 gene that is an important component of the Induced Pluripotent Stem Cells (ips). The major findings were published June 9 in the British scientific journal Nature. The researchers found that cell initialization is an indispensable step in the induction of ips cells, and the expression of this gene makes the efficient induction of ips possible.

In inducing ips cells, the virus is used as a transport vector to introduce four genes into cells such as skin. Because one of these four genes may promote cancer, yamanaka's team searched for a replacement gene.

Dr Yamanaka et al. confirmed the presence of Glis1 gene in unfertilized eggs and fertilized eggs as a substitute gene, and conducted experiments on human and mouse skin cells, and found that Glis1 gene was effective in cell initialization.

According to the experimental results, the previous success rate of mouse skin cell initialization was only 20%, but the use of Glis1 gene increased the success rate to 90%-100%. In the past, the success rate of human cell initialization was only 10%, but Glis1 could be used to increase to more than 40%.

"In order to induce safe ips cells, the world is developing techniques such as introducing genes," yamanaka said. "I think Glis1 is sort of a magic gene that induces initialization."

Last month, a team at Osaka university announced the success of a study to reduce cancer rates by eliminating the use of viral vectors, boosting research into the prevention of cancer in ips cells in Japan and abroad.
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