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Japanese researchers use stem cell transplants to repair large intestine ulcers

In a paper published in the current issue of the British journal nature medicine, Japanese researchers say they have successfully repaired large intestine ulcers in mice by growing stem cells that can grow into various types of large intestine tissue in vitro and transplanting them.

The researchers, from Tokyo medical and dental university, said they took epithelial tissue from the inner surface of the large intestine in mice and cultured it in a special way, successfully multiplying the stem cells. They then injected stem cells into the end of the digestive tracts of mice with large intestinal ulcers. As a result, these stem cells only attach to the large intestine where ulcers appear. After a month, the ulcer tissue regenerates and the ulcer disappears as if covered.

Using the same method, the team also successfully cultured stem cells from human large intestine tissue. Experts believe that if the relevant technology can be further improved, it is expected to develop new methods to treat human gastrointestinal diseases.
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