Harvard researchers of Cell stem cell journey have revealed important markers of adult stem cells
Recently researchers from Harvard University and harvard medical school and regenerative medicine, Massachusetts general hospital cancer center, the harvard stem cell institute and other institutions confirmed a maintain pluripotent stem cells and play a key role in cell reprogramming transcription factor Sox2 can be used as an important molecular markers of adult stem cells in the new study . The findings are published online in the journal Cell stem Cell.
Professor Konrad Hochedlinger, a well-known stem cell expert at the center for regenerative medicine at harvard medical school, who studied with Dr. Rudolf Jaenisch, the second leading stem cell scientist. In recent years, Hochedlinger has been praised as a dazzling new star in the international stem cell field due to a series of important contributions in the emerging field of iPS. In 2009, Hochedlinger was named the outstanding young scientist of the year by the international stem cell society.
Transcription factor Sox2 is a member of Sox gene family. Recent studies have demonstrated that Sox2 is a key factor to maintain the pluripotency of embryonic stem cells and neural stem cells. Four transcription factors, Sox2, Oct4, Nanog and Lin28, were brought into adult cells to reprogram them into induced pluripotent stem cells (iPSC).
In the study, the harvard researchers aimed to explore whether factors that play an important role in pluripotent stem cells also play a role in adult stem cells, the cell populations that sustain certain types of tissue. Through a series of mouse experiments, the researchers confirmed that Sox2 can be widely expressed in tissue-specific adult cell groups such as the stomach, esophagus, testicles, cervix, anus and lens of the eye. Since these Sox2 expressing cells can renew their populations and generate fully differentiated cells in specific tissues, it indicates that the Sox2 expressing cells in these tissues are adult stem cells. In addition, the researchers also confirmed that fetal tissue expressing Sox2 could develop into adult stem cell tissue containing Sox2. Three other transcription factors Oct4, Nanog and Lin28 were not detected in the same adult stem cells, suggesting that Sox2 may be the only transcription factor expressed in all stages of development -- embryonic, fetal and adult stem cells.
New research confirms that Sox2 is an important molecular marker widely distributed in adult stem cells, which is of great significance for scientists to develop effective new techniques for adult stem cell isolation and promote the research and application of these cells in regenerative medicine.
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