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EFTS investigates the relationship between microenvironment and stem cells and bone tumors

The 195th edition of EFTS was recently held in Shanghai. Experts at home and abroad discussed the effects of microenvironment and systemic factors on the growth of bone tumors, the research of tumor stem cells and osteosarcoma, the research of new tumor treatment technology, and the surgical treatment strategy of tumor.

Malignant tumor is one of the main causes of death in human beings, which is the second leading cause of death after heart disease. Among them, primary bone malignant tumor accounts for about 1% of adult systemic malignant tumor and 10% of children's.

Dai chilirong, an academician with the Chinese academy of engineering, said that the incidence of metastatic bone tumors, as a common complication of advanced malignant tumors, has increased significantly in recent years. According to statistics, the incidence of metastatic bone tumors accounts for about 15% ~ 20% of systemic metastatic tumors, ranking the third place after lung metastasis and liver metastasis. About 70% of breast cancer, prostate cancer and other osteophilic tumor patients have bone metastasis in the natural course of disease, and 15% ~ 30% of lung cancer, gastric cancer, colorectal cancer, renal cancer, thyroid cancer and other patients also have bone metastasis.

Clinically, primary and metastatic bone tumors often lead to severe local pain, pathological fractures, life-threatening hypercalcemia, spinal cord compression and other neurological symptoms, which seriously affect the quality of life of patients. According to the experts, bone tumors are more closely related to the microenvironment and stem cells than to other tumors due to their specific cellular origin (most bone tumors originate from mesenchymal and/or osteoblastic cells) and the location of the disease (most bone tumors tend to occur in the bone marrow cavity and adjacent tissues).

Dai said that the research on microenvironment and the relationship between stem cells and bone tumors is one of the frontiers of tumor research, which will greatly promote the progress of the pathogenesis, surface markers, molecular targets and drug research and development of bone tumors and other tumors, thus providing a new reference for the clinical treatment of bone tumors.
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