Chinese scientists propose new potential targets for the prevention, diagnosis and treatment of live
A new issue of cancer cell, one of the world's leading academic journals, has published the innovative findings of Chinese scientists in the study of liver cancer. The achievement was completed by academician Cao Xuetao, director of the immunology institute of the second military medical university and director of the state key laboratory of medical immunology, and his collaborators.
MicroRNA is a kind of single-stranded small molecule RNA with a size of about 21-23 bases, which is related to the research on the mechanism of the occurrence and development of many diseases, including cancer, and has become a hot topic in the biomedical field in recent years. Under the national "11th five-year plan" major projects funded, xue-tao cao academicians and doctoral Hou Jin, rub and professor wei-ping zhou and tsinghua university school of medicine, zhejiang university, Shanghai Oriental courage by immune surgical hospital, Shanghai changzheng hospital, zhongshan hospital affiliated to fudan university, guangxi cancer hospital, sun yat-sen university college of life science, genomics, national centers for disease control and so on 10 joint research cooperation unit, through deep sequencing technology, the microRNA group data of normal kidney, viral hepatitis kidney, hardening kidney and human kidney cancer were obtained for the first time. Biological information technology was applied to analyze the difference between kidney cancer and normal kidney microRNA group. Further, four independent clinical cohort analyses of liver cancer patients demonstrated that the low expression of microrna-199 was significantly correlated with reduced survival of liver cancer patients.
Studies have shown that microrna-199 can target to inhibit a liver cancer kinase molecule and then inhibit a downstream signal pathway, thereby inhibiting the growth of liver cancer cells, and the microrna-199 gene therapy mediated by liver targeted gonada-related virus vector can significantly prolong the survival of nude mice with liver cancer. Therefore, microrna-199 is a new potential target for the prevention, judgment and treatment of liver cancer, which provides a new method for the biological treatment of liver cancer.
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