Certain genes allow cancer stem cells to become normal cancer cells
Glioblastoma is one of the most common types of brain cancer. It often causes patients to die within a short period of time. Previous research has found that cancer stem cells are one of the causes of cancer recurrence and metastasis. Unlike normal cancer cells, cancer stem cells are able to constantly self-replicate and differentiate into a variety of cancer cells.
The team, from yamagata national university and the national cancer research center in Japan, reported that they compared the genes of normal cancer cells in glioblastoma with those of cancer stem cells and found that a gene called FoxO3a acted in normal cancer cells, but was dormant in cancer stem cells.
Animal studies have shown that when the FoxO3a gene is activated in cancer stem cells, the cancer stem cells become normal cancer cells that have no ability to proliferate and can no longer divide indefinitely.
The research is published online in the new issue of the American journal stem cell. The team has found a substance that allows the gene to work and is preparing to develop drugs based on it.
- June 18, 2019The 195th edition of EFTS was recently held in Shanghai. Experts at home and abroad discussed the effects of microenvironment and systemic factors on the growth of bone tumors, the research of tumor s...view
- May 16, 2019Schizophrenia is a kind of complex mental disease regulated by multiple genes. It is a kind of most common mental disease characterized by the division of basic personality, thinking, emotion and beha...view
- October 9, 2018In the field of stem cell research, Japanese scientists have played an important role. In 2012, Professor Yamanaka and Professor John B. Gurdon shared the Nobel Prize in Physiology or Medicine for the...view