Canada has isolated a single human blood stem cell to treat cancer
Fifty years after the discovery of stem cells, Canadian scientists have isolated the first single human blood stem cell that can regenerate the entire blood system, according to the website of the organization of American physicists, August 30 (Beijing time). The latest breakthroughs could allow scientists to treat cancer and other diseases more effectively. The research will be published in the latest issue of the journal science.
John Dick, chief professor at the Canadian institute of stem cell biology, who led the research, said the single cell isolated by the team, which can produce an entire blood system, was the key to the full potential of stem cells in clinical applications.
Stem cells are underdifferentiated and immature cells with potential functions of regenerating various tissues, organs and human bodies. They are called "universal cells" by the medical community. Ernest McCulloch and James teal of the university of Toronto first began working on stem cells in 1961. They confirmed that the blood cells came from one type of hematopoietic stem cell, and determined that the hematopoietic stem cell has the potential of self-renewal and differentiation. Then scientists began using stem cells to transplant bone marrow into blood cancer patients, the most successful clinical use of regenerative medicine to date, benefiting thousands of people each year.
Although scientists have begun to use found in umbilical cord blood stem cells, however, for many patients, a single donor samples is not enough, therefore, the scientists in the field of stem cell research has been looking for a single pure stem cells this treasure, before a single stem cell transplantation into human body, can be in a petri dish for control and extension. The latest findings could help scientists make enough stem cells for more clinical use and further the promise of regenerative medicine.
The latest study is successful, because the scientists used the technology of flow cytometry technique (FFCT), it is a kind of rapid measurement on cells or subcellular structure for analysis of the new technology and separation technology, the technology allowed scientists to quickly to pick millions of blood cells, screening and refined into meaningful binary file, so that to analyze it. Stem cell scientists can now identify the molecular switches that guide how "normal" stem cells behave and persist, and describe the core properties that distinguish ordinary stem cells from all other blood cells.
Since 1988, when dick first transplanted blood stem cells into immune-deficient mice to study human blood stem cells (also published in science), his goal has been to isolate individual human stem cells.
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