Blood substitute developed by Changchun institute of chemistry, Chinese Academy of Sciences
Changchun institute of applied chemistry, Chinese Academy of Sciences has made important progress in the research of biodegradable polymer vesicles carrying hemoglobin, the patent application of it was approved recently.
Blood transfusion is an indispensable medical means for clinical operation, disaster resistance and battlefield rescue. In recent years, the increasing demand of blood, and the safe and effective blood source is increasingly scarce, rely on people to donate blood facing shortage of blood, blood type, low temperature, short shelf life and storage transportation inconvenience, virus pollution problems such as blood transfusion safety is threatened, so the blood substitutes have been is a hot spot in the research and development of the international scientific community and business enterprises.
Jing xiabin research group, Changchun institute of chemistry, Chinese Academy of Sciences, is committed to using biodegradable polymers as the carrier of hemoglobin, using poly lysine, two block copolymerization of polyphenylene alanine peptide hemoglobin vesicle to package, trying to wrap hemoglobin vesicle, in order to obtain on the whole structure is closer to the body's red blood cells. The carrier basically meets the requirements of oxygen transport, biocompatibility, safety and stability of blood substitutes.
Compared with traditional liposomes, biodegradable polymers have unique advantages. Firstly, the polymer is biodegradable. After oxygen transport, it is degraded into amino acids, which are absorbed by the human body, and finally can be degraded into water and CO2 harmless to human body and discharged out of the body. Secondly, the structure of the polymer is easy to control. The size and aggregation mode of the hemoglobin capsule can be controlled by controlling the structure of the polymer. Finally, the strength of the polymer is better than that of the phospholipid film, and the amount of polymer film is less than that of the phospholipid film under the same conditions. Therefore, this method has potential application value in blood substitutes and brings hope to solve the problem of blood shortage.
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