A disease a medicine Allogeneic hematopoietic stem cell transplantation for the treatment of mali

During his physical examination last year, Mr. Zhang who is 32 years old , was found to have problems such as splenomegaly, lymph node enlargement, abnormal blood routine and NK lymphocytosis, and was diagnosed as chronic NK lymphocytosis by the doctor. A few months later, the patient developed symptoms such as fever, and tests found positive EB virus DNA. Further examination at the gulou hospital affiliated to the medical college of nanjing university confirmed the diagnosis of invasive NK cell leukemia with hemophagocytic syndrome. Doctors first treated the patient with intense chemotherapy to clear the leukemia cells from the patient's body, then transplanted the hematopoietic stem cells from his sister into the patient. Now the patient's blood routine has returned to normal, EB virus DNA negative.

According to the introduction of professor ouyang jian of hematology department, invasive NK cell leukemia is a rare and very dangerous hematological malignancy recognized internationally at present. It is not sensitive to conventional or intensive chemoradiotherapy, with rapid progression of disease course and extremely high mortality rate. Hematopoietic stem cell transplantation (HSCT) is the only effective treatment for this disease. Moreover, once diagnosed, HSCT must be used as soon as possible to improve the chances of life saving.

The treatment of aggressive NK cell leukemia with hemophilic syndrome with positive EB virus by whole homozygous allogeneic hematopoietic stem cell transplantation has only been reported in foreign countries, but not in China. The successful treatment of this case has fully proved that allogeneic hematopoietic stem cell transplantation has a unique effect in the treatment of invasive NK cell leukemia, a rare and malignant hematological disease. Meanwhile, it also suggests that allogeneic hematopoietic stem cell transplantation can also treat viral diseases, such as EB virus infection and AIDS.
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